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我們的研發團隊定期發表專業論文，與全球的科學家進行交流
Head-to-head comparison of brain-derived pTau217 and totalpTau217 for brain amyloid and tau pathology classification
Yuanbing Jiang, Wenyue Zheng, Zengjie Xia, Wan Wa Wong, Lily K.W. Cheng, Fanny C. Ip, Siu Man Choi, Andrew L.T. Chan, Ching Yu Lam, Ka Shing Ho, Chun Keung Shum, Jacqueline K.Y. Yuen, Yat Fung Shea, Hok Man Wai, Vincent C.T. Mok, Timothy C.Y. Kwok, Kin Y. Mok, Hiu Yi Wong, Henrik Zetterberg, Amy K.Y. Fu, Nancy Y. Ip
Proc. Natl. Acad. Sci. USA. 2 Mar 2026
Ethnic-specific effects of the LILRB2-LILRB5 locus and newly identified risk loci for Alzheimer’s disease in the East Asian population
Han Cao, Ziyu Zheng, Xiaopu Zhou, Masataka Kikuchi, Hiu Yi Wong, Elaine Y.L. Cheng, Bonnie W.Y. Wong, Ronnie M.N. Lo, Maryam Shoai, Joyce R. Chong, Andrew L.T. Chan, Christopher Chen, Linda C.W. Lam, Vincent C.T. Mok, Timothy C.Y. Kwok, Japanese Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Neuroimaging Initiative, Yu Chen, Fanny C.F. Ip, Kin Y. Mok, Akinori Miyashita, Takeshi Ikeuchi, John Hardy, Amy K.Y. Fu, Nancy Y. Ip
Alzheimers Dement. 17 Feb 2026
Targeted blood proteome profiling using NULISAseq identifies a high-performance biomarker panel for Aβ pathology quantification and staging
Wenyue Zheng, Yuanbing Jiang, Hiu Yi Wong, Wan Wa Wong, Lily K. W. Cheng, Elaine Y.L. Cheng, Bonnie W.Y. Wong, Ronnie M.N. Lo, Siu Ki Leung, Fanny C.F. Ip, Jacqueline K.Y. Yuen, Yat Fung Shea, Wai Ming Wong, Chun Keung Shum, Hok Man Wai, Vincent C.T. Mok, Timothy C.Y. Kwok, Kin Y. Mok, Amanda Heslegrave, John Hardy, Henrik Zetterberg, Amy K.Y. Fu, Nancy Y. Ip
Alzheimers Dement. 30 Jan 2026
The TREM2 H157Y variant is associated with more severe neurodegeneration in Alzheimer’s disease and altered immune-related processes
Jackie Shuk Man Tsui, Danise M. Au, Hyebin Uhm, Wan-Wa Wong, Ronnie Ming Nok Lo, Yuanbing Jiang, Fanny C.F. Ip, Kin Y. Mok, Hiu Yi Wong, Timothy C.Y. Kwok, Amy K.Y. Fu, Nancy Y. Ip
Alzheimers Dement. 17 Sep 2025
Transethnic analysis identifies SORL1 variants and haplotypes protective against Alzheimer’s disease
Xiaopu Zhou, Han Cao, Yuanbing Jiang, Yuewen Chen, Huan Zhong, Wing Yu Fu, Ronnie Ming Nok Lo, Bonnie Wing Yan Wong, Elaine Yee Ling Cheng, Kin Ying Mok, Timothy C. Y. Kwok, Vincent C. T. Mok, Fanny C F Ip; Alzheimer’s Disease Neuroimaging Initiative; Akinori Miyashita, Norikazu Hara, Takeshi Ikeuchi, John Hardy, Yu Chen, Amy K. Y. Fu, Nancy Y. Ip
Alzheimers Dement. 10 Dec 2024
Using blood transcriptome analysis for Alzheimer’s disease diagnosis and patient stratification
Huan Zhong, Xiaopu Zhou, Hyebin Uhm, Yuanbing Jiang, Han Cao, Yu Chen, Tiffany T. W. Mak, Ronnie Ming Nok Lo, Bonnie Wing Yan Wong, Elaine Yee Ling Cheng, Kin Y. Mok, Andrew Lung Tat Chan, Timothy C. Y. Kwok, Vincent C. T. Mok, Fanny C. F. Ip, John Hardy, Amy K. Y. Fu, Nancy Y. Ip
Alzheimers Dement. 7 Feb 2024
A blood-based multi-pathway biomarker assay for early detection and staging of Alzheimer’s disease across ethnic groups
Jiang Y., Uhm H, Ip F.C.F., Ouyang L., Lo RMN, Cheng E.Y.L., Cao X., Tan C.M.C., Law B.C.H., Ortiz-Romero P., Puig-Pijoan A., Fernández-Lebrero A., Contador J., Mok K.Y., Hardy J., Kwok T.C.Y., Mok V.C.T., Suárez-Calvet M., Zetterberg H., Fu A.K.Y. and Ip N.Y.
Alzheimers Dement. 6 Jan 2024
The VCAM1–ApoE pathway directs microglial chemotaxis and alleviates Alzheimer’s disease pathology
Lau S.F., Wu W., Wong H.Y., Ouyang L., Qiao Y., Xu J., Lau H.Y.J., Wong C., Jiang Y., Holtzman D.M., Fu A.K.Y. and Ip N.Y.
Nature Aging 21 Sep 2023
Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction
Zhou X., Chen Y., Ip F.C.F., Jiang Y., Cao H., Zhong H., Chen J., Ye T., Chen Y., Zhang Y., Ma S., Lo M.N.R., Tong P.S.E., Alzheimer’s Disease Neuroimaging Initiative, Mok C.T.V., Kwok C.T.V., Guo Q., Mok K.Y., Shoai M., Hardy J., Chen L., Fu A.K.Y. and Ip N.Y.
Commun Med (Lond) 6 Apr 2023
An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease
Jiang Y., Zhou X., Wong H.Y., Ouyang L., Ip F.C.F., Chau M.N.V., Lau S.F., Wu W., Wong Y.K.D., Seo H., Fu W.Y., Lai C.H.N., Chen Y., Chen Y., Tong P.S.E., Alzheimer’s Disease Neuroimaging Initiative, Mok C.T.V., Kwok C.T.V., Mok C.Y.T., Shoai M., Lehallier B., Losada P.M., O’Brien E., Porter T., Laws S.M., Hardy J., Wyss-Coray T., Masters C.L., Fu A.K.Y. and Ip N.Y.
Nature Aging 2 Jul 2022
Demographics and Medication Use of Patients with Late-Onset Alzheimer’s Disease in Hong Kong
Wong H.Y., Zhong H., Zhong M., Zhou X., Chan P.Y.C., Kwok T.C.Y., Mok K., Hardy J., Ip F.C.F., Fu A.K.Y., Ip N.Y.
J Alzheimers Dis. 16 Apr 2022
Deep learning for polygenic score analysis for Alzheimer’s disease risk prediction in the Chinese population
Zhou X., Chen Y., Ip F.C.F., Jiang Y., Cao H., Zhong H., Chen Y., Chen J., Zhang Y., Ma .S, Lai N.C.H., Lo R.M.N., Cheung K., Tong E.P., Mok K.Y., Hardy J., Guo Q., Mok V.C.T., Kwok T.C., Chen L., Fu A.K.Y. and Ip N.Y.
Alzheimers Dement. 3 Dec 2021
Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer’s disease alleviates amyloid-related pathologies in mice
Duan Y., Ye T., Qu Z., Chen Y., Miranda A., Zhou X., Lok K.C., Chen Y., Fu A.K.Y., Gradinaru V. and Ip N.Y.
Nat Biomed Eng. 26 Jul 2021
Large-scale plasma proteomic profiling identifies a high-performance biomarker panel for Alzheimer’s disease screening and staging
Jiang Y., Zhou X., Ip F.C., Chan P., Chen Y., Lai N.C.H., Cheung K., Lo R.M.N., Tong E.P.S., Wong B.W.Y., Chan A.L.T., Mok V.C.T., Kwok T.C.Y., Mok K.Y., Hardy J., Zetterberg H., Fu A.K.Y. and Ip N.Y.
Alzheimers Dement. 25 May 2021
Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases
Ye T., Duan Y., Tsang H.W.S., Chen Y., Cao H., Chen Y., Fu A.K.Y. and Ip N.Y.
Communications Biology 2 Feb 2021
Quantitative in vivo assessment of amyloid-beta phagocytic capacity in an Alzheimer’s disease mouse model
Lau S.F., Wu W., Seo H., Fu A.K.Y. and Ip N.Y.
STAR Protocols 19 Jan 2021
Astrocyte-secreted IL-33 mediates homeostatic synaptic plasticity in the adult hippocampus
Wang Y., Fu W.Y., Cheung K., Hung K.W., Chen C., Geng H., Yung W.H., Qu J.Y., Fu A.K.Y. and Ip N.Y.
Proc. Natl. Acad. Sci. USA. 5 Jan 2021
Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease
Lau S.F., Cao H., Fu A.K.Y. and Ip N.Y.
Proc. Natl. Acad. Sci. USA. 28 Sep 2020
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